Highly Efficient Method for
C-5 Halogenation of Pyrimidine-Based Nucleosides in Ionic
Liquids

Vineet Kumar; Jeremy Yap; Andrew Muroyama; Sanjay V. Malhotra

doi:10.1055/s-0029-1217042

PAPER

Highly Efficient Method for C-5 Halogenation of Pyrimidine-Based Nucleosides in Ionic Liquids

Vineet Kumar, Jeremy Yap, Andrew Muroyama, Sanjay V. Malhotra*
Laboratory of Synthetic Chemistry, SAIC-Frederick Inc., NCI-Frederick, 1050 Boyles Street, Frederick, MD 21702, USA
Fax: +1(301)8465206; e-Mail: malhotrasa@mail.nih.gov;

Abstract

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Abstract

A novel, highly efficient, convenient, and benign methodology for C-5 halogenation of pyrimidine-based nucleosides has been developed using N-halosuccinimides as halogenating reagents without using any catalyst in ionic liquid medium. The ionic liquids were successfully recovered and reused for all the reactions.

Key words

ionic liquids - nucleosides - halogenation

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References

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